| Customization: | Available |
|---|---|
| CAS No.: | CAS:2381089-83-2 |
| Formula: | C221h342n46o68 |
|
Still deciding? Get samples of US$ 0.02/mg
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
| Storage temp. | -20°C |
|---|---|
| Form | powder |
| Appearance | White lyophilized |
| Water Solubility | Soluble in water (5mg/ml). |
| Function | weight loss |
Retatrutide Chemical Properties,Uses,Production
Retatrutide is a novel triple agonist peptide of the glucagon receptor (GCGR), glucose-dependent in-sulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R). Retatrutide inhibits human GCGR, GIPR and GLP-1R with EC50 values of 5.79, 0.0643 and 0.775 nM, respectively and mouse GCGR, GIPR, and GLP-1R with EC50 values of 2.32, 0.191 and 0.794 nM, respectively. It is an important tool for obesity research.
Retatrutide potently activates the GLP-1R signaling pathway to stimulate glucose-dependent in-sulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R.
Retatrutide is a synthetic peptide with glucose-lowering effects. It is an antidiabetic agent against type 2 diabetes (T2D), stimulating in-sulin and suppressing glucagon secretion in a glucose-dependent manner.
Retatrutide was also shown to delay gastric emptying, lower fasting and postprandial glucose concentration, decrease food intake and reduce body weight in patients with type 2 diabetes.
Retatrutide (LY3437943), a single peptide conjugated to a lipid diacid molecule, exerts a powerful agonist effect on the human glucagon‐receptor (GCGR), GIPR, and GLP‐1R. In comparison with the human glucagon and glucagon‐like peptide 1 (GLP‐1), retatrutide exhibits reduced potency (by a factor of 0.3 and 0.4, respectively) on the GCGR and GLP‐1R while displaying enhanced potency at the human GIPR (by a factor of 8.9) when compared to the glucose‐dependent in-sulinotropic polypeptide (GIP)[7].
When injected into mice suffering from diabetes-induced kidney injury, retatrutide was found to markedly reduce albuminuria levels while also increasing renal filtration rate. This was attributed to its ability to activate GLP-1R/GR-dependent signalling pathways, which then produced anti-inflammatory and antiapoptotic effects that protected the kidneys from further damage. Additionally, it has been shown to directly modulate glomerular permeability, thus leading to improved urinary concentration. Initial results indicate that the peptide can induce marked improvements in albuminuria levels within just four weeks of treatment when compared to other treatments for chronic kidney disease such as ACE inhibitors or angiotensin receptor blockers (ARBs). Moreover, retatrutide has demonstrated a greater effect than either ACE inhibitors or ARBs at reducing systolic blood pressure without inducing significant side effects.
The most common side effects of retatrutide are gastrointestinal, including: Nausea, Diarrhea, Vomiting, and Constipation. At higher doses, researchers stated these symptoms were "mostly mild to moderate in severity" and typically treated by lowering the dosage. However, 7% of patients also experienced skin tingling. At 24 weeks of treatment, patients' heart rates on higher doses peaked but declined afterward.
Main Marketing :
North America, South America, Eastern Europe
Who we are ?:
Nanjing XYX Technology Co.,Ltd is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products; Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and customerized products due to our clients' requirement. Our professional sales team focuses on quality and after service, and our team leader has been on excellent experience and perfect performance over the 10 years. With our constant efforts and good service, We expect to establish long-term cooperation and common development with our customers sincerely .
THE KEY : WORK WITH US
PRODUCT DEVELOPMENT :
Portflio management
Identification and justification of development candidates
Marketing research
Project management
Patent research and evaluation
Coordination of development activities
Business development
Our Sourcing : Marketing &sales :
Qualification of API-manufacturers Global marketing and sales
GMP-Consulting Storage in our own GMP-compliant warehouse
Audits Well control supply chain
Customer preparation of inspections Just-in-time supply
Support during inspections Representative offices worldwide
Compilation and registration of DMF'S
RFQ
Q: How to start orders or make payments?
A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How to confirm the Product Quality before placing orders?
A:You can get samples for some products to test. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q: What's your MOQ?
A:For the high value product, our MOQ starts from 1box.
Q: Is there a discount?
A: Yes, for larger quantity, we always support with better price.
Q:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q:How to contact us ?
You can choose your interested products and send inquiry to us.
You can dial our telephone directly.
){kind=link}