| Customization: | Available |
|---|---|
| CAS No.: | 129954-34-3 |
| Formula: | C33h57n11o9 |
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| Product Name | Selank peptide |
| CAS | 129954-34-3 |
| Other Names | Selankpeptide;SelankAcetate;PL14736;L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline;L-THREONYL-L-ChemicalbookLYSYL-L-PROLYL-L-ARGINYL-L-PROLYLGLYCYL-L-PROLINE;MONOACETATE;H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH;SLANK;Selankpeptid |
| Molecular Formula | C33H57N11O9 |
| Molecular Weight | 751.87 |
| Apperance | lyophilized powder |
| Color | white |
The peptide Selank has been labeled as an "anti-anxiety" peptide and has also shown improvement in learning, memory, cognition, depression, weakness, and overall energy.
While most prescription drugs cause many unwanted side effects, studies have shown this peptide to have no negative side effects or risk of addiction. Both Tuftsin and Selank have shown the ability to reduce anxiety and increase serotonin levels in animal models.
Additionally, selank may:
Selank can strengthen immune function by increasing IL-6 in blood cells. IL-6 is an inflammatory protein that is believed to help fight off infections. Selank can also stimulate the release of interferons, which are anti-viral molecules.
Selank demonstrates unique immunomodulatory effects, making it a potential therapeutic agent in anxiety-asthenic disorders. Research in vitro indicated that Selank suppressed gene expression of interleukin-6 (IL-6) in patients with depression but not in healthy controls. Interestingly, an increase in IL-6 concentration was observed in cell cultures from the peripheral blood of patients when treated with Selank. Furthermore, a 14-day course of Selank in patients with generalized anxiety disorder (GAD) and neurasthenia resulted in changes in the Th1/Th2 cytokine balance. These findings suggest that Selank may act as an immunomodulator, with adaptogenic properties beneficial for elderly people and those exposed to environmental stressors, potentially helping prevent infectious diseases.
A study involving 62 patients with GAD and neurasthenia showed that Selank exhibited anxiolytic effects similar to those of me-dazepam, a classical ben-zodiazepine, but with additional antiasthenic and psychostimulant properties. During treatment with Selank, patients with GAD demonstrated increased serum levels of tau(1/2) leu-enkephalin, correlated with reduced anxiety and asthenia symptoms. Additionally, Selank has been shown to alter the expression of genes involved in inflammation in mouse spleen, suggesting its role in regulating inflammatory processes. The synthetic peptide caused changes in the expression of 34 genes related to inflammation, with notable alterations in the Bcl6 gene, crucial for immune system development.Selank is derived from the endogenous tetrapeptide tuftsin, and has been extensively studied for its effects on learning, memory, and serotonin (5-HT) metabolism in rats. In one experimental setup, rats trained with food rewards were injected with either Selank (300 micrograms/kg) or saline after the 10th trial in a series of 30 trials per day. The experiment continued 30 minutes later with elaboration of conditioned reflex and later testing of retention after 24 hours, 7 days, and 30 days. The results showed that Selank activates 5-HT metabolism in the hypothalamus and caudal brainstem within 30 minutes to 2 hours of administration. Moreover, Selank injection during the consolidation phase led to increased memory trace stability over 30 days, suggesting that it could play a role in enhancing memory storage processes.
Beyond anxiety, Selank appears to directly boost cognitive functions, as indicated by its impact on memory trace stability. This effect is notable as it is independent of the animal's anxiety levels, implying that Selank has a more direct influence on memory and learning. Additional studies showed that Selank could modify the expression of several genes in the hippocampus and affect the mRNA levels of 36 different genes, most of which are associated with plasma membranes. These results suggest that Selank could modulate ion-dependent processes involved in learning and memory, highlighting its potential as a cognitive enhancer.
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